Paper Information

Title: 

PROPERTIES OF LONG-TERM POTENTIATION AT TWO TYPES OF EXCITATORY SYNAPSES IN LAYER VI OF MOUSE VISUAL CORTEX

Type: POSTER
Author(s): TSUMOTO T.*
 
 *RIKEN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Layer VI of the visual cortex is an origin of feedback connections from the cortex to the thalamus and has a strong influence on firing properties of thalamocortical relay cells. Despite this important role, little attention has been paid to synaptic plasticity of layer VI neurons. As inputs to layer VI originate mostly fromsuperficial layers and the underlying white matter, we studied long-term potentiation (LTP) of excitatory synapses to layer VI pyramidal neurons in slice preparations of the mouse visual cortex. Accordingly, excitatory postsynaptic potentials (EPSPs) evoked by layer II/III or white matter stimulation were recorded using the patch clamp method. Theta burst stimulation of layer II/III or white matter paired with postsynaptic depolarization induced LTP in almost all of the pyramidal neurons. Analysis with the paired-pulse stimulation protocol suggested that both types of LTP may be postsynaptic in origin. Further analyses should be made to determine whether the two types of LTP have the same or different properties.

 
Keyword(s): LTP, VISUAL CORTEX, PATCH CLAMP, LAYER VI, MOUSE
 
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