Paper Information

Title: 

ASSESSING THE EFFECT OF FGF-2 ON MYELIN REPAIR IN MOUSE OPTIC NERVE AND CHIASM USING VISUAL EVOKED POTENTIAL RECORDING

Type: POSTER
Author(s): DEHGHAN SAMANEH,POURABD ALHOSSEINI F.,JAVAN MOHAMMAD,MIRNAJAFIZADEH S.J.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Demyelination in CNS, is usually followed by remyelination. However chronic lesions with subsequent functional impairment are resulted from eventual failure of remyelination process as seen in multiple sclerosis. Remyelination is the process through which oligodendrocyte progenitor cells (OPCs) restore new myelin sheathes around demyelinated axons. Factors which increase OPCs proliferation, migration and differentiation could be used to improve remyelination. In current study the repairing effect of FGF-2 on lysolecithin induced demyelination in mouse chiasm and optic nerve was investigated.
Methods: For demyelination induction, lysolecithin was injected streotaxically into the optic nerve and chiasm of Balb/C mice. Two groups of animals received FGF-2 (1 or 5 ng/Kg-i.p.) just before and every three days after lysolecithin injection and the delay of visual evoked potential (VEP) recording was recorded as an index of neural conductivity at 7th, 13th and 28th days post lesion. Results were compared with those obtained from control animals which received lysolecithin.
Results: Injection of lysolecithin into the optic nerve and chiasm resulted in an increased delay for VEP at 7th, 13th and 28th days post injection. The maximum delay was observed at 7th day. Injection of FGF-2 reduced the increase in delay of VEP and returned it to the normal value at 13th and 28th day post lysolecithin injection.
Conclusion: Injection of FGF-2 could prevent the lysolecithin induced increase in delay time of VEP. It seems that FGF-2 may decrease lysolecithin induced demyelination and potentiate remyelination process.

 
Keyword(s): DEMYELINATION, REMYELINATION, MULTIPLE SCLEROSIS, FGF-2, GROWTH FACTORS, VEP, MOUSE
 
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