Paper Information

Title: 

THE STUDY OF RELATIONSHIP BETWEEN LEFT AND RIGHT LOCUS CEORELEOS IN FORMALIN TEST IN RATS

Type: POSTER
Author(s): SAJEDIANFARD J.*,NAZARIAN ZAHRA
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF VETERINARY MEDICINE, SHIRAZ UNIVERSITY, SHIRAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Locus Ceoreleus (LC) like some other nuclei in central nerves system has two parts in hemispheres and may have some connections to each others. This connection can affect their ability to change pain control. In this study, 30 rats (280±30g) in six groups were used (3 test groups and 3 controls groups). In test groups, 0.5μl lidocaine was injected in left LC (group 1), in right LC (group 2) and in both LC (group 3) to make local anesthesia. In control groups (4-6), 0.5μl normal saline was injected. After 15 minutes, 50μl of 2.5% formalin was injected subcutaneously to left hind paw of rats and nociception was detected at every 15 seconds for one hour. The results showed that injection of lidocaine in both LC produced more nociception in rats than lidocaine injection in left LC alone. The latter group, in turn, showed more nociception than the group receiving right LC lidocaine injection. The effect of lidocaine was more detectable between first and second phase of formalin test. No significant differences were seen among control groups. This study concluded that left and right LC have a significant effect on unidirectional nociception in formalin test in rats, but the contralateral LC has less influence on this nociception.

 
Keyword(s): LOCUS CEORELEUS, NOCICEPTION, LIDOCAINE, LATERALITY
 
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