Paper Information

Title: 

MORPHINE DEPENDENCE DOES NOT CHANCE BASELINE SYNAPTIC RESPONSE

Type: POSTER
Author(s): HOSSEINMARDI N.,FATH ELAHI Y.*,JAVAN MOHAMMAD,NAGHDI N.
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Addictive drugs are thought to alter normal brain function and cause the remodeling of synaptic functions in areas important for memory and reward. Given the known effects of opiates such as morphine on hippocampal function, we investigated the potential effect of chronic morphine treatment on baseline synaptic response and paired pulse index (PPI) at CA1 synapses of rat hippocampal slices. Population spikes were recorded from stratum pyramidale following stimulation of schaffer collaterals. There was no significant difference in the baseline synaptic response of slices taken from control or dependent rats across all stimulus intensities. Also morphine and naloxone had no effect on baseline responses of both groups. The mean paired pulse index (PPI) was <1 for the 10 and 20 ms inter pulse intervals (PPD: Paired Pulse Depression) and >1 for 80 and 200 ms inter pulse intervals (PPF: Paired Pulse Facilitation) in the control and dependent animals. A significant increase in PPI was observed in the dependent slices at 80 ms inter pulse intervals (IPI) as compared to the control ones. Morphine application caused an increase of PPI at 20 ms IPI in dependent slices compared to control ones in vitro. These results suggest that chronic morphine treatment does not change baseline synaptic responses but increases paired pulse facilitation in CA1 synapses.

 
Keyword(s): ADDICTION, CA1 NEURAL NETWORKS, BASELINE SYNAPTIC RESPONSE, PAIRED PULSE INDEX
 
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