Paper Information

Title: 

THE EFFECT OF ASCORBIC ACID ACUTE INJECTION ON MORPHINE WITHDRAWAL SYNDROME IN MICE

Type: POSTER
Author(s): FARHADINASAB A.A.,RAOUFI SAFOURA*,SHAHIDI SIAMAK,ALAH VERDIPOUR H.
 
 *HAMEDAN UNIVERSITY OF MEDICAL SCIENCE
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Introduction: Recent studies indicate that the glutamatergic system is involved in morphine withdrawal syndrome by locus coeruleus stimulation. Ascorbic acid releases from glutamatergic neurons and modulates them. This study evaluated the effect of acute dosages of ascorbic acid on withdrawal syndrome in mice.
Methods: Animals were given increasing dosages of morphine for 4 days. On day 5 they received acute dosages of ascorbic acid. After naloxone injection withdrawal signs were studied for 30 min.
Results: Acute injection of ascorbic acid decreased morphine withdrawal signs.
Conclusion: Acute injection of ascorbic acid attenuates withdrawal syndrome probably via glutamatergic neurons modulation.

 
Keyword(s): ACUTE INJECTION, ASCORBIC ACID, WITHDRAWAL SYNDROME
 
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