Paper Information

Title: 

EFFECTS OF POLYGALA PLATYPTERA ON MORPHINE WITHDRAWAL SYNDROME IN MICE

Type: POSTER
Author(s): KOUREHPAZ MAHMOUDABADI MAHDIEH*,GOHARI A.R.,SAEIDNIA SOUDABEH,HAJI AKHOUNDI A.,SHARIFZADEH MOHAMMAD,GOUHARI MAHMOUD
 
 *MEDICINAL PLANTS RESEARCH CENTER, FACULTY OF PHARMACY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Detoxification and rehabilitation of opioid addicts are important concerns as drug abuse has caused severe problems for both abusers and society. Polygala platyptera Bornm. & Gauba, named Shirafza in Persian (milkwort), belongs to the Polygalaceae family and has been traditionally used as a remedy for enhancement of milk production in Iran. Because of a report on the antagonistic effect of P. telephioides (growing widely in China) on morphine responses in mice, we aimed to evaluate the antagonistic effect of P. platyptera on morphine withdrawal syndrome in order to support the usage of herbal medicine for management of opioid withdrawal. Air-dried aerial parts of the plant (65 g) were cut in to small pieces and percolated consequently with ethyl acetate and methanol. After filtering, the solutions were concentrated under reduced pressure to gainethyl acetate (1.5 g) and methanol (16 g) extracts. The mice were randomly divided into 4 groups (n=7). All animals were rendered dependent on morphine by subcutaneous (sc) injection of morphine at 3 doses of 50, 50 and 75 (mg/ kg) per day for three days. On the fourth day, one dose of morphine (50 mg/kg) was injected to all groups before treatment with naloxone. After induction of morphine dependence, distilled water was injected to control group. Various concentrations of methanol (5, 25, 50 and 100 mg/kg) and ethyl acetate extracts (5, 25, 100 and 200 mg/kg) were injected to other groups. Two hours after the last injection of morphine, withdrawal signs appeared by injection of naloxone (5 mg/kg, sc). Immediately, the number of jumping episodes was counted for 60 minutes. All concentrations of the methanol extract produced statistically significant decreases in development of morphine dependence compared to the control group. Ethyl acetate extract also decreased jumping episodes in the test group at doses 25, 100 and 200 mg/kg. We can therefore suggest the use of this plant in management of addiction.

 
Keyword(s): POLYGALA PLATYPTERA, MORPHINE DEPENDENCE, WITHDRAWAL SYNDROME, NALOXONE
 
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