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Paper Information

Title: 

L-ARGININE REDUCES THE EXPRESSION OF PLACE AVERSION INDUCED BY NALOXONE IN MORPHINE-TREATED RATS

Type: POSTER
Author(s): KARIMI SARA*,KARIMI MANIZHEH,SADRAEI H.
 
 *DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, SHAHED UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

As evidence shows there is a correlation between positive reinforcement of morphine and drug dependency. Naloxone is used to manifest opiate dependency. This study was conducted to investigate morphine conditioning in naloxone paired environment by exposure to a single injection of naloxone. A 3 day unbiased conditioning procedure was used to establish place preference in adult male Wistar rats weighing 200-250g. Naloxone (0.05-0.4 mg/kg, ip) was given prior to testing. Nitric oxide (NO) doners (0.3-3 μg/rat) were administered into the central amygdala. Morphine (2.5-7.5 mg/kg, sc) dose-dependently produced a significant place preference. Naloxone (0.05-0.4 mg/kg, ip) induced a significant place aversion, a response reversed by direct injection of L-arginine. The present data may reflect the involvement of NO in naloxone-dependent place aversion in morphine conditioning task. This result can open a new window to find out more information on morphine reward.

 
Keyword(s): MORPHINE, L-NA, L-ARGININE NO, NALOXONE
 
 
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