Paper Information

Title: 

EFFECT OF REM SLEEP DEPRIVATION DURING PREGNANCY ON LTP INDUCTION AND MAINTANANCE IN THE HIPPOCAMPAL CA1 AREA OF ADULT MALE OFFSPRING RATS

Type: SPEECH
Author(s): HAGHPANAH TAHEREH*,SHEYBANI VAHID,AFARINESH M.R.,ABBASNEZHAD MAHDI,ESMAEILI MAHANI SAEID
 
 *BIOLOGY DEPARTMENT OF SHAHID BAHONAR UNIVERSITY OF KERMAN, KERMAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In addition to behavioral failures, Prenatal stress (PS) influences learning and memory in rat litters. In this experiment, the stressful effect of REM-sleep deprivation of pregnant rats on hippocampal Long-Term Potentiation (LTP) has been studied on adult male offspring. Pregnant animals (Wister strain) were divided into three separate groups. REM sleep deprived group (Small Platform; SP), which were deprived from REM sleep for 72 hours at E14-E16 days; In pedestal control group (Large Platform; LP, without REM-sleep deprivation), pregnant animals cared alike for the period of 72 hours and in control group itself (no Platform), the pregnant left without any interventions in segregated cages. Field potential recordings gathered from two-month old offspring. Following 30 minutes of baseline recording and applying high frequency stimulation (HFS; 10 bursts, 100 HZ, 0.002 S intervals) onto collateral Schaffer pathway, field potential recordings intended for 90-minute period were taken from CA1 region of the hippocampus.
Our results indicate that percent of change of slope, amplitude and the area under curve of fepsp in baseline recording did not show significant differences among groups. After applying HFS, LTP was induced in all three groups. However, HFS caused an increase in maintenance of the fepsp criteria in control and LP groups compared to SP group, but induced-LTP and its maintenance did not differ significantly between control and LP groups. Our results showed that REM sleep deprivation during pregnancy reduces plasticity of hippocampal neurons measured by LTP in adult offspring.

 
Keyword(s): PREGNANCY, REM SLEEP DEPRIVATION, LTP, CA1 HIPPOCAMPUS, RAT
 
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