Paper Information

Title: 

EXERCISE DURING PREGNANCY: THE EFFECT ON OFFSPRING COGNITIVE FUNCTION

Type: SPEECH
Author(s): MOHAMMAD AKHAVAN M.*,EMAMI ABARGHOUEI M.,SAFARI MANOUCHEHR,SEDIGHI MOGHADAM B.,VAFAEI ABAS ALI,BANDEGI A.R.,FOROUTAN TAHEREH,RASHIDIPOUR A.
 
 *SKIN RESEARCH CENTER, LABORATORY OF PROTEIN AND ENZYME, SHAHID BEHESHTI UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Brain-derived neurotrophic factor (BDNF) plays a central role in the molecular cascade of events, which is triggered by voluntary exercise. However, our knowledge about the positive effects of voluntary exercise during pregnancy on offspring cognitive function and the mechanism(s), which is involved, is still primary. Male wistar rats were allowed to mate with female virgin wistar rats (210±10 g) during a 24 hours period. The pregnant rats have been randomly assigned to sedentary or voluntary exercise groups. Each of the voluntary exercise (V.exercise) pregnant rats was given access to a running wheel (diameter=34.5cm, width= 9.5cm) (freely rotated against a resistance of 100g), until the end of their pregnancy. Each wheel was attached to a counter that monitored its revolutions. We administered K252a or Cytochrome C. via injection of fluorescent latex microspheres directly and bilaterally into the right and left hippocampus of the male rat pups on PND 59. After the injections, rats were used to perform MWM test. The rats born from V.exercise mothers had significantly lower latencies to locate the platform compared with S.control group on the days 3 (P<0.01) and 4 (P<0.01) of their training. And the animals in the V.E.k252a showed significantly increased latency to find the platform compared to V.E.control group on the days 3 (P<0.05) and 4 (P<0.05). Our behavioral data support the hypothesis that BDNF through TrkB receptors play an important role in mediating the effects of maternal V.exercise in pregnancy on offspring cognitive function.

 
Keyword(s): EXERCISE, COGLITIVE FUNCTION, PREGNANCY
 
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