Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

INTERACTION BETWEEN THE PARAVENTRICULAR NUCLEUS Y1/Y5 RECEPTORS AND OREXIN-1 RECEPTORS IN REGULATION OF BASAL GASTRIC ACID SECRETION IN CONSCIOUS RATS

Type: SPEECH
Author(s): KERMANI MOJTABA*,ELIASI AFSANEH,NAGHDI N.
 
 *NEUROSCINCE RESEARCH CENTER AND DEPARTMENT OF PHYSIOLOGY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Orexins and NPY play an important role in the central nervous system to modulate gastric acid secretion. Within the hypothalamus, expression of orexin-1 receptors (OX1R), Y1 and Y5 receptors are greatest in the paraventricular nucleus (PVN). Therefore, we hypothesized that interaction between PVN Y1/Y5 receptors and OX1R may be involved in the control of gastric acid secretion. To addresse this question, we examined the effect of PVN microinjection of orexin-A in Y1 andY5 antagonists treated rats on gastric acid secretion. After fixing the animal in a sterotaxic instrument, the PVN and lateral ventricle cannulation were performed. Intra-PVN microinjections of orexin-A (5 μg) and saline, icv microinjection of Y1 (GR231118; 30, 15, 7.5 and 5 μg) and Y5 (CGP71683; 30, 15 and 5 μg) antagonists and saline, and pylorus ligation were performed under brief ether anesthesia. One hour after treatments, the animals were sacrificed and the stomach was removed. Acid output was determined by titration of gastric samples to pH7. Results showed that the icv microinjection of Y5 antagonist decreased gastric acid secretion (GAS) in a dose-dependent manner, while the inhibitory effect of Y1 antagonist was dose independent. In contrast, intra-PVN injection of orexin-A increased GAS. We found that Y1 and Y5 antagonists suppressed stimulated gastric acid secretion induced by orexin-A. This study demonstrates that stimulatory effect of endogenous NPY on GAS is mediated by Y1 and Y5 receptors. We also suggest that there is an interaction between OX1R and Y1/Y5 receptors in the regulation of GAS.

 
Keyword(s): Y1/Y5 RECEPTORS, OREXIN-1 RECEPTORS, GASTRIC ACID SECRETION
 
 
Yearly Visit 38   tarjomyar
 
Latest on Blog
Enter SID Blog