Paper Information

Title: 

MEDIAN AND LATERAL HYPOTHALAMUS NUCLEUSES PHARMACOLOGIC INTERACTION ON DOPAMINE AGONISTIC AND ANTAGONISTIC

Type: SPEECH
Author(s): TOUSHIH MOHAMMAD,KARIMIAN MORTEZA
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In the central nerve system there are variety of centers and nucleuses which control the exocrine glands of digesting system. Hypothalamus median and lateral nucleuses are of the important areas which control exocrine glands. These nucleuses are related to tubero-infundibular system, and increase digesting system activity when using neuroleptic medicines. Hypothalamus nucleuses are full of dopamine receptors which control major part of metabolism activity by stimulation and lateral block process. In the present study two most important nucleuses, median and lateral nucleuses are under consideration, and simultaneously with injecting antagonist dopamine into these nucleuses they take control of activity level of salvia sub-jaw glands (mandibular) and secreting glands of gastric acid (oxintic cells). Physiological analysis shows that medicines and their agonistic derivatives of dopamine receptors effects brain stem of related nucleus and salvia and gastric through effecting on dopaminergic and tubero-infundibular and as a result decrease amount of salvia and gastric secretion and in contrast antagonist medicines of dopamine receptors increase secretion of these glands through effecting on the same centers on brain stem.
In pharmacology point of view there is special relation between median nucleuses and lateral hypothalamic, so that receptors type is of no concern. Dopamine receptors have distribution in two section of pre-synapse and post-synapse on the nucleuses, and their actions are synergic is some paths and anti-synergic in some other paths. Pharmacologic analysis shows that, dopamine agonists have stimulation effect, on pre-synapses receptors, and on pre-synapses they will show their resistive action and dopamine antagonists have resistive effect on both pre and post- synapses.

 
Keyword(s): HYPOTHALAMUS NUCLEUSES PHARMACOLOGIC INTERACTION, TUBEROINFUNDIBULAR DOPAMINERGIC SYSTEM, AGONIST AND ANTAGONIST MEDICINES DOPAMINESALVIA AND GASTRIC ACID SECRETION
 
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