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Paper Information

Title: 

PROTECTIVE EFFECT OF OXYTOCIN ON CARDIAC INFARCTION IN ANESTHETIZED RAT HEART

Type: SPEECH
Author(s): HOUSHMAND F.*,FAGHIHI MAHDIEH,ZAHEDIASL S.,IMANI A.R.,NADERI ROYA
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Ischemic heart disease is a serious medical problem that can result in cardiac injury and heart failure. Recent studies indicate that neuropeptide oxytocin (OT) is involved in the regulation of cardiovascular functions. The aim of the present study was to test the hypothesis that OT induces cardioprotective effects on ischemia reperfusion–induced (I/R) myocardial damage. In this study, anesthetized rats were subjected to 25 min of ischemia and 120 min of reperfusion. Myocardial ischemia was surgically induced by means of left anterior descending coronary artery occlusion. OT (10-10 -10-8 M. i.p.) administrated 30 min prior to coronary ligation. Infarct size was measured by the triphenyltetrazolium chloride (TTC) and expressed as a per cent area at risk (%AAR). Result showed that after 120 min of coronary artery reperfusion, OT significantly decreased infarct size (25.3±6.1 (P<0.05) and 16.2±2.8 (P<0.001), in 10-9 and 10-8 M groups respectively) compared with control (41.9±1.8). In conclusion, these results indicate that OT may have a cardioprotective role against ischemia-reperfusion injury in the anesthetized rat heart and exert this protection in a dose-dependent manner.

 
Keyword(s): OXYTOCIN, ISCHEMIA/REPERFUSION, INFARCT SIZE
 
 
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