Paper Information

Title:  THE ROLE OF NMDA GLUTAMATE RECEPTOR OF CUNEIFORM NUCLEUS ON THE CARDIOVASCULAR RESPONSE IN ANAESTHETIZED RATS
Type: SPEECH
Author(s): SHAFEI M.N.*,NASIMI A.,ALAEI H.A.
 
 *DEPTARTMENT OF PHYSIOLOGY, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Cuneiform nucleus (CnF) is a reticular nucleus of the midbrain involved in the cardiovascular functions. It was shown that electrical and chemical stimulation of the CnF caused an increase in arterial blood pressure and excitation of sympathetic vasomotor discharge. However, there is no study on the cardiovascular effects of the glutamate and its receptors subtypes in the CnF. In the present study we investigated the cardiovascular effects of glutamate and its NMDA receptor in the CnF of rat. Glutamate (0.25M) and AP5, a NMDA receptor antagonist (5mM) stereotaxically were microinjected (50 nl) into the CnF of anaesthetized rats. The blood pressure and heart rate were recorded throughout the experiment. The maximum change of mean arterial pressure and heart rate was compared with the pre-injection (paired t-test) and control (independent t-test) value. Microinjection of glutamate into the CnF produced two types of responses: 1) short pressor and bradycardic; 2) long pressor and tacycardic responses. Microinjection of AP5 alone did not change the basal arterial pressure and heart rate, however, co- injection of glutamate and AP5 significantly attenuated the mean arterial pressure (n=16, P<0.001) and heart rate (n=16, P<0.01) responses to glutamate. In Conclusion, cardiovascular effects of glutamate in the CnF may be mediated through both NMDA glutamate receptors.

 
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