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Paper Information

Title: 

ISCHEMIA AND REPERFUSION INDUCED ARRHYTHMIAS: ROLE OF NORMOBARIC HYPEROXIC PRECONDITIONING

Type: SPEECH
Author(s): POURKHALILI KH.*,HAJIZADEH S.,AKBARI ZAHRA,ESMAEILI DEHAJ MANSOUR,KHOUSHBATEN A.
 
 *DEPARTMENT OF PHYSIOLOGY, BUSHEHR UNIVERSITY OF MEDICAL SCIENCES, BUSHEHR, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Hyperoxic preconditioning is known to protect the heart against necrosis and contractile dysfunction, but protection against arrhythmias has not been well characterized. The authors hypothesized that pre-exposure to normobaric hyperoxia (H) reduces ischemia and reperfusion induced arrhythmias in isolated rat’s heart. Following 60 and 180 min of hyperoxia treatment, rat hearts were isolated immediately (H60 and H180) or 24 hours afterward (H60/24 and H180/24), and subjected to 30 min of regional ischemia followed by 120 min of reperfusion. Occurrence, number, and duration of arrhythmias were analyzed during ischemia and reperfusion. In addition, cardiac infarct size was also assessed. The results showed that 60 and 180 min of breathing hyperoxic gas induced significant protection against severe ischemia and reperfusion induced arrhythmias. Total number of premature ventricular beats was markedly attenuated by hyperoxia pre-exposure especially in H60 and H180 groups. VT (Ventricular tachycardia) and VF (Ventricular fibrillation) duration was also affected by hyperoxia. Hyperoxia reduced the number of VT episodes in ischemia and reperfusion phase. Accordingly, severity of arrhythmias (arrhythmia score) and infarct size was lower by hyperoxia treated groups. The effects were more pronounced using hyperoxia immediately before harvesting the heart. In conclusions, the results indicate that hyperoxic preconditioning attenuates ventricular ischemia and reperfusion induced arrhythmias in isolated rat heart, decreases cardiac infarct size and improves postischemic heart function.

 
Keyword(s): HYPEROXIA, ISCHEMIA AND REPERFUSION ARRHYTHMIAS, INFARCT SIZE, ISOLATED RAT HEART
 
 
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