Paper Information

Title: 

THE EFFECT OF EXPERIMENTALLY INDUCED HOPOTHYROIDISM DURING FETAL LIFE ON ORGANS FUNCTIONS OF THE OFFSPRING DURING ADULTHOOD

Type: SPEECH
Author(s): ZAHEDIASL S.*
 
 *ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY (M.C), TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

In the stage of fetal life, cell numbers increase, development is progressed and differentiation is occurred. Barker's theory states that any deviation from normal condition and alternation in the uterine environment during fetal life not only effect the normal progress of fetal growth but also may have long lasting impact which appear during adulthood of the offspring. Occurrence of hypertension and diabetes in adult life due to changes in the diet of the mother during gestational period is a few examples of such effects. Thyroid hormones play essential roles in the development of many tissues and organ, and have a significant effect on the physiology of the most organs. The role of these hormones in the development and differentiation of the central nervous system during fetal and neonatal periods have been very well established. Nevertheless this role of the hormones on the other organs has not been studied extensively. This laboratory has studied the effect of propylthiouracil induced hypothyroidism in the mothers during gestational period on the contractility of the isolated aorta and also the carbohydrate metabolism of the adult offspring. Study shows that although the offspring is not hypothyroid at the time of the study (adulthood), contractility of the aorta is decreased. Also, glucose tolerance is diminished and insulin secretion capacity of the isolated islets is reduced. One can conclude that fetal hypothyroidism can pave the ground for the appearance of abnormal vascular function and diabetes during adult life.

 
Keyword(s): FETAL, HYPOTHYROIDISM, GLUCOSE TOLERANCE, ISOLATED ISLETES, INSULIN SECRETION
 
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