Paper Information

Title: 

ROLE AND EFFECT OF FINASTERIDE ON PROSTATE GLAND OF MATURE NMRI MOUSE IN VIVO AND IN VITRO

Type: SPEECH
Author(s): PARIVAR KAZEM,YAGHMAEI PARICHEHR,SEKHAVATI SAHAR*
 
 *DEPARTMENT OF BIOLOGY, SCIENCE AND RESEARCH BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Finasteride, a 4-azasteroid, is a specific and competitive inhibitor of type 5a-reductase - an intracellular enzyme that converts testosterone into 5a- dihydrotestosterone. Finasteride is used in treatment of benign prostatic hyperplasia (BPH). In the present study, the effect of human dose of finasteride on the tubules diameter and thickness, and weight of prostatic dorso-lateral lobules were investigated both in vivo and in vitro. In vivo, 18 mature NMRI mice were divided into 3 groups (n=6) - control group (without treatment), sham group (treatment with physiologic serum) and experimental group (treatment with finasteride) via intraperitoneal injection of 5mg/kg/day during 7 days. In vitro, prostatic dorso-lateral lobules of 18 mice were divided into 3 groups (n=6) - control group (fixation without treatment), sham group (treatment with physiologic serum) and experimental group (treatment with finasteride) via culture of 5mg/kg/day during 3 days. Data were analyzed using SPSS software and Tukey test. P≤0.05 was considered significant. Finasteride, in vivo, caused a significant reduction in tubules diameter and thickness. Weight of prostatic dorso-lateral lobules were also significantly reduced in comparison with control and sham groups. Furthermore, finasteride, in vitro, caused a significant reduction in tubules diameter and thickness in comparison with control group. On the basis of results, finasteride can affect prostate gland in vivo and in vitro, in short-and long-term.

 
Keyword(s): FINASTERIDE, PROSTATE, TESTOSTERONE, DIHYDROTESTOSTERONE, TYPE॥ 5 α-REDUCTASE
 
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