Paper Information

Title:  HYPOGLYCEMIC AND ANTIDIABETIC EFFECTS OF THE FRACTIONS OF PHOENIX DACTYLIFERA PALM LEAF EXTRACT ON ALLOXAN-INDUCED DIABETES IN RAT
Type: SPEECH
Author(s): MARD S.A.*,BALOUCHI HODA,JAFARNEZHAD MASOUMEH,JALALVAND KOUSAR,GHARIB NASERI MOHAMMAD KAZEM
 
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Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

This study evaluated the hypoglycaemic and antidiabetic effects of the fractions of phoenix dactylifera palm leaf extract (PDE) in alloxan-induced diabetic rats. The hydro-alcoholic extract was fractionated through successive solvent extraction, and the acute effect of one dose of its subfractions (200 mg/kg, p.o.) with ethylacetate, chloroform and remaining aqueous fractions were investigated using normal, glucose-hyperglycaemic rats and alloxan-induced diabetic rats. Also the subacute (14 days) effects of the subfractions (200 mg/kg) were evaluated in alloxandiabetic rats. Glybenclamide was used as a positive control at a dose of 4 mg/kg. Blood samples were taken for glucose measurement on the 1st, 6th, 10th and 14th days. The body weight and water intake were determined. Subacute administration of PDE subfractions in alloxan-induced diabetic rats showed a significant (P<0.01) antihyperglycemic activity by lowering blood glucose. Among PDE subfractions, chloroform fraction showed the most prominent antihyperglycaemic effect. PDE subfractions treatment enhanced the body weight and decreased water intake (p<0.01). PDE administration up to 8 g/kg did not manifest any toxic signs in rats. The study showed that the PDE subfractions have an antihyperglycaemic effect. The results of preliminary phytochemical study showed that the extract is rich in flavonoids and phenols. Our results suggest that the hypoglycaemic effect of the subfractions is mediated by flavonoids and phenols.

 
Keyword(s): ALLOXAN, ANTIHYPERGLYCEMIC, PHOENIX DACTYLIFERA LEAF, RAT
 
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