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Paper Information

Title: 

EFFECT OF MATERNAL DIABETES ON SUBICULUM NEURONAL DENSITY IN NEONATAL RATS

Type: SPEECH
Author(s): TEHRANIPOUR M.*
 
 *ISLAMIC AZAD UNI
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Effect of Maternal Diabetes on subiculum Neuronal Density in Neonatal Rats Tehranipour Maryam Department of Biology, Faculty of Science, Islamic Azad University- Mashhad Branch, Mashhad, Iran. Background: Pregnant women who suffer from diabetes are more likely to have a child with memory problems. In addition of vascular dysfunctions, maternal diabetes induces some changes in brain structure in infants. The present study has been undertaken the effects of maternal diabetes on subiculum and Hyppocampus structure in 1 day neonate individuals rats from diabetic mothers in both control and diabetic groups.
Methods: Diabetes was induced by stereptozotocin (55mg/kg) given by a single intraperitoneal injection to female Wistar rats. Control rats were injected with phosphate buffered saline. After parturition 2 pups were randomly selected from each litter, their brain dissected, fixed in 10% formalin, sectioned in 7μm thickness and stained by H.E. By applying stereological techniques and systematic random the number of neurons in CA1, CA2, CA3 and subiculum was measured in both control and experimental groups.
Results: These studies were on pyramidal cells in CA1, CA2, CA3 and subiculum it has been shown that the experimental maternal hyperglycemia in rats results neuronal loss and damage expressed maximally in CA3 and subiculum. Although in experimental groups there is a remarkable neuronal density decrease in all hippocampus sectors, but it is meaningful in CA3 and subiculum (p<0.05).
Conclusion: This observation has allowed us to postulate that the neuronal death in the infant from diabetic mothers proceeds on an apoptotic pathway. That may be the reason for memory problems in these neonates. Key words: maternal diabetes, subiculum, hyperglycemia.

 
Keyword(s): MATERNAL DIABETES, SUBICULUM, HYPERGLYCEMIA
 
 
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