Paper Information

Title: 

EFFECT OF VINEGAR ON SOME RISK FACTORS OF ATHEROSCLEROSIS AND ATHEROSCLEROTIC LESIONS IN RABBITS FED A CHOLESTEROLRICH DIET

Type: SPEECH
Author(s): SETORKI MAHBOUBEH*,NAZARI B.,ASGARY SEDIGHEH,EYDI AKRAM,HAERI ROUHANI SEYED ALI
 
 *DEPARTMENT OF BIOLOGY, SCIENCE AND RESEARCH CENTER, ISLAMIC AZAD UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Atherosclerosis, the leading cause of death in developed countries, is a complex disease with many proved risk factors. Vinegar, a condiment commonly used, has been proved to have some medical uses and some potential protective effects on atherosclerosis. In this research, we have investigated effects of vinegar on various risk factors of atherosclerosis and on the development of atherosclerosis in hypercholesterolemic rabbit.
Rabbits were assigned to 4 groups and each group received one of experimental diets: normal diet, high cholesterol diet (1% cholesterol), 1% cholesterol supplemented with 5ml vinegar and 1% cholesterol supplemented with 10ml vinegar for 8 weeks. Blood samples were collected before and after 8 weeks of experimental diets for measurement of C-reactive protein (CRP), nitrite, nitrate, fibrinogen, factor VII, apolipoprotein A( ApoA) and apolipoprotein B (ApoB). At the end of study, fatty streak formation in aorta artery was determined using Chekanov method in all groups.Using 5, 10 ml vinegar with cholesterolemic diet caused significant reduce in CRP, fibrinogen , factor VII, ApoB100, ApoB/ApoA ratio, atherosclerotic lesions in aorta artery and increased nitrite, nitrate in comparison with hypercholesterolemic diet. .No significant difference was found between doses of vinegar compared with high cholesterol diet in ApoA1 (p>0.05).
These results suggest that vinegar reduced hypercholesterolemic atherosclerosis. This is likely due to antioxidant and anti-inflammatory effects of vinegar.

 
Keyword(s): VINEGAR, ATHEROSCLEROSIS, FATTY STREAK, RISK FACTOR
 
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