Paper Information

Title: 

EVALUATION OF ORIGANUM VULGARE L. SSP. VIRIDIS LEAVES EXTRACT ON LOCOMOTOR ACTIVITY, DISCRIMINATION LEARNING AND LTP INDUCTION & ITS MAINTENANCE IN THE CA1 REGION OF RAT HIPPOCAMPUS

Type: SPEECH
Author(s): AFARINESH M.R.*,SHEYBANI VAHID,ABBASNEZHAD MAHDI,HAJI ALIZADEH Z.,HAGHPANAH TAHEREH,ARABNEZHAD R.
 
 *KERMAN NEUROSCIENCE RESEARCH CENTER, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

The objective of our study was to determine the effect of aqueous extract of Origanum Vulgare L. ssp. Viridis on Locomotor activity, Discrimination learning and Long Term Potentiation (LTP) in CA1 region of the rat hippocampus. In this study, a group of adult wistar male rats weighing 275±25 gr were fed aqueous extract of origanum (150, 300, 450 mg/kg/day, intraperitoneal injection) for one week, and the other group received saline (n=6). Subject's locomotor activity was confirmed by trying on an accelerating Rotarod apparatus. A reduced-latency was shown in origanum treated-animals compared to that of saline group (significant at dose of 450mg/kg, p<0.05). A wooden T-maze was used to evaluate the discrimination learning. Statistic analysis has shown that origanum aqueous decreased the number of training (300, 450mg/kg) and error (300mg/kg) in Tmaze procedure significantly (p<0.05). In electrophysiological study, subjects, which received origanum (300 mg/kg), showed a high induction and maintenance of LTP in CA1 hippocampus after high frequency stimulation (200Hz) in Schaffer collateral pathway. Our results showed that origanum aqueous extract could improve the learning criteria and decrease locomotor activity in rats.

 
Keyword(s): MEDICAL PLANT, ORIGANUM VULGARE, LOCOMOTOR ACTIVITY, T-MAZE APPARATUS, LONG-TERM POTENTIATION, SPATIAL LEARNING
 
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