Paper Information

Title: 

EFFECTS OF NATURAL ANTIOXIDANTS, GROWTH HORMONE, AND PHYSOSTYGMINE, ON AD-LIKE COGNITIVE DEFICIENCY IN NBMLESIONED RATS

Type: SPEECH
Author(s): SARKAKI A.R.*,ZAHEDIASL S.,MOTAMEDI F.,KHAKSARI HADAD M.,HAERI ROUHANI SEYED ALI,AMANI R.,FARBOUD Y.,ZAND MOGHADAM A.,DOULAH A.A.H.,MALEK MARYAM,SAFAHANI M.,VALIPOUR CHAHARDAH CHERIK SAEID,KIASAT E.,AZHDARI H.
 
 *PHYSIOLOGY RESEARCH CENTER, DEPARTMENT OF PHYSIOLOGY AND NUTRITION, AHVAZ JONDISHAOUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Effects of soy, grape seed extract (GSE), growth hormone (GH), and physostygmine administration was evaluated by behavioral, electrophysiological and microdialysis methods to prevent and/ or improve the AD-like cognitive deficiency in NBMlesioned rats. In this study, male and female (ovariectomized) young and aged Wistar rats were used. NBM was lesioned bilaterally by injection of ibotenic acid 0.5μg.0.1μl-1 in each side). After recovery, stereotaxic surgery was done to implant a guide cannula for central injection, stimulating and recording electrodes and also a microdialysis probe for fEPSP, LTP recording and neurotransmitter measurement, respectively. Animals were trained in Y-maze (active avoidance task), T-maze and Morris water maze (spatial training) for behavioral studies. 5-10 rats were in each group. Data were analyzed by student’s t-test, one-way and two-way ANOVA fallowed by HSD or LSD post-hoc tests. Results show that: oral administration of soy and GSE for one month before lesioning to NBM and Subcutaneouse or intrahippocampus injection of GH, intra-cortex, intra-septum, and intra-amygdala injection of physostygmine have significant preventive or improvement effects on cognitive, electrophysiological and neurotransmitter changes in rats. These effects may be due to their antioxidative, neuroprotective, or GH deficiency compensatory effects, or prevention of Ach inactivation and/or glutamate release in brain.

 
Keyword(s): ALZHEIMER’S DISEASE, SOY, GSE, GH, PHYSOSTYGMINE, COGNITION, RAT
 
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