Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

THE CB1 RECEPTOR ANTAGONIST WITHIN THE NUCLEUS ACCUMBENS REDUCED THE ACQUISITION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MORPHINESENSITIZED RATS

Type: SPEECH
Author(s): AZIZI P.*,MOUADAB M.,HASANPOUR EZATI M.,HAGHPARAST ABAS
 
 *NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

It has been shown that cannabinoids interact with the opiate system in rewardrelated behaviors and in animal models of addiction. In the present study, the effects of bilateral intra-accumbal administration of AM251, a CB1 receptor antagonist, on the acquisition of ineffective dose of morphine-induced conditioned place preference (CPP) in morphine-sensitized rats was studied. The results showed that subcutaneous (s.c.) administration of morphine (0.25, 0.5, 0.75, 1, 2.5 and 5 mg/kg) induced CPP only at the dose of 5 mg/kg. In addition, repeated administration of morphine (5 mg/kg; s.c.), once daily for three days that followed by 5 days without any treatment (sensitization period), increased conditioning response induced by ineffective doses of morphine (0.25, 0.5 and 0.75 mg/kg). Bilateral intra-accumbal administration of AM251 (5, 25 and 125 ng/0.5 μl per side) reduced the acquisition of morphine-induced CPP in morphine-sensitized rats in a dose dependent manner. Bilateral intraaccumbal administration of neither saline nor DMSO (0.5 μl/side) had effects on the acquisition of morphine-induced CPP in sensitized rats. The results indicated that CB1 receptor within the nucleus accumbens is involved in the sensitization to opiates.

 
Keyword(s): REWARD, CB1 RECEPTOR, SENSITIZATION, NUCLEUS ACCUMBENS, ACQUISITION, RAT
 
 
Yearly Visit 44   tarjomyar
 
Latest on Blog
Enter SID Blog