Paper Information

Title: 

PROTECTIVE EFFECTS OF COBRA VENOM NAJA NAJA OXIANA (NOX) DURING VESTYIBULAR COMPENSATION FOLLOWING UNILATERAL LABYRINTHECTOMY

Type: SPEECH
Author(s): KHALAJI N.*,HAMBARDZUMYAN L.E.,MANUKYAN L.P.,CHAVUSHYAN V.A.,SARKISIAN V.H.,SARKISSIAN J.S.
 
 *URMIA UNIVERSITY OF MEDICAL SCIENCES, DEPARTMENT OF HOSPITAL EMAM, URMIA, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

It is known that unilateral labyrinthectomy (UL) causes a syndrome of oculomotor, postural and autonomic system disorders, which diminish over time in a process of behavioral recovery known as vestibular compensation. The object of this study was to determine the effect of administration of Cobra venom naja naja oxiana (NOX), as a new natural biological resource agent on unilateral labyrinthectomy on row impulse activity changes and Ca2+ dependent acidic phosphotase activity in Deiters’lateral vestibular nucleus (LVN) of rat. Albino rats were randomly divided into three groups (n=9): control, unilateral labyrinthectomized and unilateral labyrinthectomized treated by naja naja oxiana.
At 9th day of treatment, the electrical activity of neurons in paraventricular (PVN) and supraoptic (SON) nuclei of hypothalamus were recorded. Post stimulus activity of LVN neurons was revealed as tetanic potentiation (TP) and depression (TD). Also, the histochemical properties of neurons were revealed by mean of revealing the activity of Са2+-dependent acidic phosphate in LVN neurons. In unilateral labyrinthectomized and NOX treated groups was established the compensatory increase of effects (TD and TP) compared to the control group.
The findings of this study indicate that NOX enhanced the vestibular compensation mediated by GABA receptor during recovery of failed functions following vestibular damage. The data of this study indicate the NOX venom as an effective protector, which successfully promote the vestibular compensation.

 
Keyword(s): VESTIBULAR COMPENSATION, DEITERS’ LATERAL VESTIBULAR NUCLEUS, UNILATERAL LABYRINTHECTOMY, RAT
 
Yearly Visit 16   tarjomyar
 
Latest on Blog
Enter SID Blog