Paper Information

Title: 

EFFECT OF LONG-TERM MORPHINE ADMINISTRATION ON PANCREATIC HORMONES AND SERUM GLUCOSE LEVELS IN RAT

Type: SPEECH
Author(s): RADAHMADI MARYAM*,SHARIFI MOHAMMAD REZA,AMINI MASOUD,FESHARAKI MEHRAFARIN
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2009Volume 19
 
 
Abstract: 

Since short-term morphine use changes serum glucose (SGL), serum insulin (SIL) and serum glucagon levels (SGLL) and also addiction is relatively frequent in the society; this proposal is based on long-term morphine use (LTMU) in order to determine a possible causal link between morphine and glucose, insulin and glucagon levels. 16 male Wistar rats initally weighing 200- 250g were divided to 2 groups (n=8). Morphine dependency was induced by giving increasing doses of morphine by intraperitoneal (ip) injection. Animals were injected with 10, 20, 30, 40, 50, 60 mg/kg morphine sulfate on day 1, 2, 3, 4, 5, 6 respectively and the dose of 60 mg/kg was repeated for 20 more days. Duration of experiment was 26 days. After the experiment, blood samples were collected, serum glucose levels measured by the glucose oxidase method, and serum insulin and glucagon levels by radioimmunoassay. Our results showed that LTMU caused an insignificant increase in SGL (24.14% and development of hyperglycemia), an insignificant increase in SIL (3.58%) and an insignificant decrease in SGLL (20.16%). Morphine administration over this period of time led to a permanent hyperglycemic effect but did not result in diabetes mellitus and just induced a prediabetic condition in nondiabetic Rats. Despite an increased SGL, SGLL did not elevate. Hence, it seems that the hyperglycemic effect of morphine might be a result of a increase in the level of other effective hormones; increase in adrenaline and norarenaline secretion; or else inhibition of glucose clearance. In addition, it is probable that morphine, through increasing serum adrenaline level and inhibiting somatostatin secretion, augments SIL.

 
Keyword(s): GLOCOSE, MORPHINE, GLUCAGON, INSULIN, DIABETES
 
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