Paper Information

Title: 

EFFECTS OF OLANZAPINE ON THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED BEHAVIORAL SENSITIZATION IN FEMALE MICE

Type: POSTER
Author(s): HAFEZ AMINI P.*,SAHRAEI HEDAYAT,KHAKPOUR B.
 
 *DEPARTMENT OF VETERNITY, SCHOOL OF AGRICULTURE, ISLAMIC AZAD UNIVERSITY, RASHT, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The prevalance of opioid addiction is releativly high in Iran. Since the mechanism (s) of opioid addiction is not clear, this social problem is still remained unresolved. In the present study, the effects of different doses of olanzapine as a dopamine receptor antagoninst on the acquisition and expression of morphine-induced behavioral sensitization in male N-MARI mice (20-30 g) were investigated.
Methods: Sensitization was induced by single injection of morphine (5 mg/kg) in three consecutive days followed by five days resting. On the 9th day of the experiments, the sensitization was assessed in animals by a single injection of very low dose of morphine (0.5 mg/kg). Olanzapine was administered during or after induction of morphine sensitization. Then, the sensitizations were tested in the animals. In order to evaluate the effects of the drugs on locomotor activity, morphine and olanzapine were administered to the animal in a pilot study.
Results: Results showed that administration of morphine (10 and 20 mg/kg), induced a significant activity in the animals. On the other hand, administration of olanzapine (1, 2.5 and 5 mg/kg) produced a significant hypoactivity in the animals. Injection of the same olanzapine (1and 2.5 mg/kg) 20 min before the morphine (5 mg/kg) administration in the traning days, caused a significant decrease in locomotor activity in animals, i.e. reduced the acquisition of morphine-induced behavioral sensitization. Injection of olanzapine (1, 2.5 and 5 mg/kg) in the test day, 20 min before morphine (5 mg/kg) administration also reduced the locomotor activity in the animals in a dose-independent manner, i.e. reduced the expression of morphine-induced behavioral sensitization.
Conclusion: It can be concluded that olanzapine may inhibit locomotor activity in mice and  also acquisition and expression of morphine-induced behavioral sensitization in female mice as well.

 
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