Paper Information

Title: 

THE EFFECT OF ORAL ADMINISTRATION OF RETINOIC ACID ON PAIN THRESHOLD OF ACUTE AND CHRONIC PAIN MODELS TAIL- IMMERSION- TEST AND FORMALIN TEST

Type: POSTER
Author(s): HAJI ALIZADEH Z.,AFARINESH M.R.,SHEYBANI VAHID,BADINLOU M.,SHAMSIZADEH ALI
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Vitamin A and its derivatives have recently been reported to be implicated in inflammatory responses. The aim of the present study was to analyze the pain threshold of rats which were tested by Tail - Immersion - test and Formalin test.
Methods: thirty- five adult NMRI male rats were divided into five groups (n=7) as follow: Retinoic acid (40000, 80000, 120000IU/KG) was administrated for 2 weeks by gavage (0.1ml/kg B.W), 30 minutes prior to the experiments. The four groups (sham) received distilled water and the last group (control) received nothing. In tail immersion - test each animal treated one trial behavioral test 30 minutes after the last dose injection. In Formalin test, formalin (5µl, S.C) was injected into right hand in two different phases (5 min as acute pain and 5-45 min as chronic pain).
Results: Results showed that Retinoic acid (40000, 80000IU/KG) reduced response latency withdrawal of rat's tail (p<0.05). In Formalin test Retinoic acid (80000IU/KG) decrease pain threshold in acute pain (p<0.05) but pain threshold chronic pain didn't change.
Conclusion: This study showed oral administration of Retinoic acid decrees pain threshold of rats.

 
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