Paper Information

Title: 

PHYSIOLOGIC EFFECTS OF ECSTASY AT MOLECULAR LEVEL: THE ROLE OF SYNAPTOSOME

Type: SPEECH
Author(s): HOSSEINI S.M.*
 
 *PHYSIOLOGY-PHARMACOLOGY DEP., GOLESTAN UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: The most important effects of ecstasy and other amphetamine derivatives are euphoria, lessening of anxiety and feeling of closeness and empathy. Sever hypertension, rising of blood pressure, organ failure and brain dysfunctions are the most important complications of these compounds. They change synaptic concentration of aminergic and serotonergic neurotransmitters by non-vesicular release. Application of synaptosome in investigating this process is important.
Aim: Introducing an efficient In Vitro model for studying non-exocytotic release of neurotransmitters by ecstasy.
Methods: Experimental data of spontaneous and evoked release obtained from rat cerebellar synaptosome. All other data was collected by systematic review of recent studies.
Results: Carrier mediated and vesicular releases were differentially shown using synaptosome superfusion, in addition all presynaptic proteins (ion channels, receptors and transporters) and their modulations were well preserved.  Ecstasy can induce non-vesicular release by binding to presynaptic aminergic carriers especially the serotonin transporter (SERT). Reduction of SERT number, decreasing of central serotonergic synapses, uptake of toxic metabolites of ecstasy, depletion of vesicular store, induction of thyroxin hydroxylase, inhibition of monoamine oxidase, alternation of intravascular PH, decreasing of proton gradient, block of vesicular accumulation and changing membrane permeability are other mechanisms of ecstasy complications.
Conclusion: Synaptosome as an isolated chemical synapses has unique properties for study of ecstasy neurotoxicity. 

 
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