Paper Information

Title: 

EFFECT OF AMINOGUANIDINE ON POST-ISCHEMIC BRAIN EDEMA FORMATION IN TRANSIENT MODEL OF FOCAL CEREBRAL ISCHEMIA

Type: POSTER
Author(s): HOSSEINZADEH F.*,VAKILI ABEDIN,ZAHEDI KHORASANI M.,HOSSEINZADEH SEYED AHMAD
 
 *LABORATORY OF CEREBROVASCULAR RESEARCH, PHYSIOLOGICAL RESEARCH CENTER, UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Brain edema is one of the most important mechanisms responsible for brain damage and mortality after ischemic stroke. Despite considerable efforts, no specific therapy is available yet. Aminoguanidine (AG) is a drug were used in clinical for treatment some of disease. Previous studies have shown AG neurprotective effect in experimental model of cerebral ischemia. However, effects AG on cerebral edema almost have not yet been investigated in transient model of focal cerebral ischemia.
Methods: Transient focal cerebral ischemia was induced in rats by 60 minutes middle cerebral artery occlusion, followed by 23 hours reperfusion. Effect of AG at doses 75, or 150, or 300 mg/kg ip on brain edema was assessed by dry-wet methods.
Results: Administration AG (150 mg/kg ip) at the beginning of Middle cerebral artery occlusion significantly reduced the post-ischemic increase of brain water content (P<0.001), while AG at dose 75 and 300 mg/kg did not significant affect (P>0.05).
Conclusion: Our findings show that administration of AG in early phase of transient focal cerebral ischemia reduces brain edema. This finding may is useful for stroke patients.

 
Keyword(s): 
 
Yearly Visit 11   tarjomyar
 
Latest on Blog
Enter SID Blog