Paper Information

Title:  THE EFFECT OF ATYPICAL ANTI PSYCHOTICS ON THE MEMORY IN SCHIZOPHRENIA
Type: POSTER
Author(s): HASANZADEH P.*
 
 *DEPARTMENT OF PHYSIOLOGY & PHARMACOLOGY, KURDISTAN UNIV. OF MED. SCI., SANANDAJ, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Anti psychotics such as clozapine have been extensively prescribed in schizophrenia. clozapine therapy is not associated with extrapyramidal side effects as seen with typical antipsychotics. Cognitive disorders are usually accompanied by schysophrenia, which should be considered as a medical problem. The present study was designed to evaluate the effect of clozapine on the memory in the rat model of schizophrenia.
Methods: New born female and male Sprague Dawley rats were used and the hippocampus deterioration was induced on the 7th day of birth.Win-shift method in radial maze was used for the appropriate experiments in the adult rats. On the 7th session of learning, the experimental group received repeated injections of clozapine (2.5 mg/kg) and the control groups received saline for 12 sessions.
Results: According to the results, both clozapine and hippocampus deterioration induced cognitive disorders in the female rats; however in male rats, only administration of clozapine had been resulted to cognitive disorders.
Conclusion: It seems that clozapine itself and through the potentiation of hypocampus disorders lead to the cognitive impairments and the gender play an important role in this regard.

 
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