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Paper Information

Title: 

THE EFFECT CAPTOPRIL ON MORPHINE SELF ADMINISTRATION IN RAT

Type: POSTER
Author(s): HOSSEINI M.,ALAEI H.A.,SHARIFI M.R.,JAFARI M.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objective: The mechanisms of drug dependence have not been known exactly and several neurotransmitters are involved. It is possible that the renin angiotensin system have interaction with opioid system because angiotensin II and ACE inhibitors have analgesic effects and in some cases they could antagonize the effects of morphine. In the present study the effect of captopril on morphine self administration was evaluated.
Method: Male wistar rats trained to receive small pellets by pressing active lever in self administration apparatus. Then jugular vein was cannulated and stainless steel cannula was inserted in the brain right ventricle. After recovery the animals were placed in the self administration apparatus for 11 days and 2 hours in a day. The animals received 0.1 ml of morphine (morphine and captopril groups) and 0.1 ml of saline (saline group) by pressing active (but not passive) lever. Before each session captopril (captopril group) or saline (saline and morphine group) was injected intracerebroventricularly. Finally the number of active and passive lever pressing in each group and among different groups was compared.
Results: Number of active and passive lever pressed was significantly different in morphine group (P<0.001). Number of active lever pressed in morphine group was significantly higher than saline group in the final three days (P<0.001). In captopril group there was not significant difference between active and passive lever pressed number in the last 5 days and number of active lever pressed was significantly lower than that morphine group (P<0.001).
Conclusion: This study shows interaction between renin angiotensin system and opioid system but itneeds more investigations.

 
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