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Paper Information

Title: 

PROTECTIVE EFFECT OF SAFRANAL ON PENTYLENETETRAZOL-INDUCED SEIZURES IN THE RAT: INVOLVEMENT OF GABAERGIC AND OPIOIDS SYSTEMS

Type: SPEECH
Author(s): SADEGHNIA H.R.,HOSSEINZADEH HOSSEIN
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

The aim of the present study was to evaluate the effects of safranal, an active constituent of Crocus sativus L. stigmas, on seizures induced by pentylenetetrazol. Intracerebroventricular (I.C.V.) microinjection of safranal (4.84, 9.68 and 24.2 µmol) had no effects on tonic and clonic phases as well as mortality upon seizures induced by PTZ (90 mg/kg ip). However peripheral administration of safranal (72.75, 145.5 and 291 mg/kg, ip) induced a dose-dependent decrease in the incidence of both minimal clonic seizures (MCS) (145.5 mg/kg, p<0.01) and generalized tonic-clonic seizures (GTCS) (145.5 mg/kg, p<0.001) following PTZ administration. Safranal also increased MCS and GTCS latency, significantly. Percent of protection against GTCS was 30%, 100% and 100% and mortality protection percent was 40%, 100% and 100% for the mentioned doses, respectively. Pretreatment with flumazenil (5 nmol, icv) and naloxone (5.5 nmol, icv and 2 mg/kg, ip), 15 min. prior to safranal administration (145.5 mg/kg, ip), abolished the protective effect of safranal on MCS. Flumazenil also decreased the effect of safranal on incidence as well as latency of GTCS, significantly. However these effects were not significant for naloxone (5.5 nmol, icv and 2 mg/kg, ip).
Results of this study demonstrated that safranal could exert anticonvulsant activity in PTZ model and this effect may be mediated, at least partly, through GABAA benzodiazepine receptor complex.

 
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