Paper Information

Title: 

THE ROLE OF GALANIN IN THE INHIBITORY EFFECT OF LOW FREQUENCY STIMULATION ON PERFORANT PATH KINDLING

Type: SPEECH
Author(s): SADEGH MAHDI*,MIRNAJAFIZADEH S.J.,JAVAN MOHAMMAD,FATH ELAHI Y.,MOHAMMADZADEH MOHAMMAD,JAHANSHAHI ALI
 
 *DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY, TEHRAN, I.R., IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Low frequency stimulation (LFS) of the kindled site interferes with seizure acquisition. In the present study, we examined the role of galanin receptors in the inhibitory effect of LFS on kindled seizures induced by electrical stimulation of perforant pathway.
Methods: Animals were stimulated daily at the AD threshold intensity whit a rapid kindling procedure (6 stimulations daily for 60 min, on consecutive days. Repeated stimulations were spaced 10 min apart). In LFS groups immediately after cessation of each kindling stimulation LFS was applied through stimulating electrodes for 10 minute. In control and LFS groups, M35 (0.5 and 1.0 nM per site) a nonselective galanin receptors antagonist was microinjected in to the dentate gyrus to block the effects of galanin. M35 was microinjected daily before the beginning stimulation protocol.
Results: LFS application retarded the kindling rate. It increased the number of stimulations needed to reach seizure stages 4 and 5. LFS also decreased the cumulative afterdischarge duration during the first 10 days of stimulation. Intra-dentate gyrus microinjection of M35 (0.5 and 1.0 nM) reduced the inhibitory effect of LFS on kindling rate significantly.
Conclusion: These data indicate that, galanin receptors may have a role in mediating the inhibitory effect of LFS on perforant kindled seizures.

 
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