Paper Information

Title: 

THE EFFECTS OF RATS EXPERIMENTAL DIABETES MELLITUS ON DEVELOPMENTAL PARAMETERS, PAIN THRESHOLD, LEARNING AND MEMORY OF ADULT OFFSPRING

Type: SPEECH
Author(s): SARKAKI A.*,AHMADIAN SH.,BADAVI M.,FARBOUD Y.
 
 *AHWAZ JONDISHAPOUR, UNIV. OF MED. SCIENCES, PHYSIOLOGY RESEARCH
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Parental insulin-dependent diabetes mellitus is associated with an increased risk of congenital malformation, pain threshold alteration, weight loss, and cognition impairment in the offspring. However, little is known about the effects of diabetes of one or both parents before coupling on CNS integrative and physical parameters of body in the offspring. To begin the gain an understanding of this problem, diabetes was induced in adult male and female Wistar rats (as parents) by injection with streptozotocin (STZ, 60 mg/kg, i.p.). Only animals with serum glucose levels greater than (FBS 250 mg/dl) were used. Diabetic and normal rats were coupled randomly as NMNF, NMDF, DMNF, and DMDF groups (5 females + 3 males in a cage). All newborn pups were bred; one month old male and female offspring were housed in different cages separately to 3 months. Their body weight and height were measured on birthday ,after 1-4 weeks, and 2-3 months. Pain threshold, spatial learning and memory of the adult offspring were evaluated. Results show that weight of diabetic parents pups (one or both) was less than with normal parents significantly from birthday to 90 days olds. Height did not different, but pain threshold, spatial learning and memory impaired significantly in the offspring with diabetic parents (one or both). In conclusion, hyperglycemia or diabetes in one or both parents before coupling may associate with some serious risks for body growth and integrative processing in CNS during prenatal and also postnatal development. Thus, on base of these finding we suggest consideration of diabetes people before wedding as other diseases.

 
Keyword(s): 
 
Yearly Visit 19   tarjomyar
 
Latest on Blog
Enter SID Blog