Paper Information

Title: 

THE EFFECTS OF HYPOTHYROIDISM ON WISTAR RAT SPERMATOGENESIS

Type: SPEECH
Author(s): NIKRAVESH M.R.,JALALI MAHDI
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

OBJECTIVE: Previous studies have shown that thyroid hormones (T3 and T4) play important role for postnatal development and maturation. In this study, the effect of hypothyroidism on spermatogenesis 2 month age Wistar rats were investigated.
METHODS: The animals were divided into experimental and control groups. The experimental group were made hypothyroid by chemical thyroidectomy with propylthyourasil (PTU). The control was remind untreated. After 3 week, the animals were scarified and testes were fixed in formalin for histological studies.
FINDINGS: Our data indicated that, hypothyroidism resulted in significant reduction in seminiferous tubule and lumen diameter. Control rats showed active spermatogenesis whereas in hypothyroid rats, the proliferation and differentiation of germ cells were arrested and their number was decreased.
CONCLUSION: The present study clearly indicates that hypothyroidism adversely affects spermatogenesis; it also indicates that thyroid hormones are essential for normal spermatogenesis.

 
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