Paper Information

Title: 

ASSESSMENT OF CYTOTOXIC EFFECTS OF OMNIPAQUE 350 ON SPERMATOGENESIS IN MOUSE MODEL

Type: SPEECH
Author(s): PARVIZI SH.*,MOZDARANI H.,SOULATI M.
 
 *DEPT. OF RADIOBIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIVERSITY
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The worldwide use of non ionic contrast media in radiological examinations is being increased very fast. There are not many studies on effects of these materials on spermatogenesis. This research was performed to study the probable cytotoxic effects of omnipaque 350 (a non ionic iodinated contrast material) on spermatogenesis in mouse model.
Methods: The different doses of 0.5, 1, 2, 3, 4 ml/kg of omnipaque 350 were injected via tail vein of the 5 groups of 5 mice. The mice were killed 20 days after injection. Testis weight of all groups of mice was compared with the control group and then their testicular sperm heads were counted using haemocytometer under a light microscope (×400). The mean numbers of sperm heads in each group were compared with the control group and survival fractions (SF) were measured.
Results: The mean numbers of sperm heads in all injected groups in comparison with control group showed statistically significant differences in all doses of omnipaque 350. The most decrease in the number of sperm heads occurred at lowest dose (1.0 ml/kg) (p<0.001). Testis weight loss was also noted within the same group in comparison with the control group (p=0.057). The figure clearly shows the decrease of survival fractions of sperm heads in all doses of omnipaque 350 on spermatogenesis.
Conclusion: The results show that omnipaque 350 causes an obvious decrease on spermatogenesis in all doses and the most effective dose is 1.0 ml/kg. The testis weight loss is seen in this dose too. It is recommended that using of omnipaque 350 to be restricted in patients with known history of fertility problems.

 
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