Paper Information

Title: 

TRANSDERMAL DELIVERY OF NITRIC OXIDE (NO) THROUGH NO-COMPLEXES IN A RAT MODEL

Type: SPEECH
Author(s): SHAABANI MOHAMMAD,LAJEVARDI MARJAN,JAHANGIRI NOUDEH Y.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: NO generated and delivered site-specifically by transdermal donors may be useful in the treatment of various skin infections without causing systemic side effects.
Objective: To investigate transdermal application of NO-complexes in a rat model.
Methods: Sixteen male Sprague-Dawley rats (mean weight: 87.4±2 gr.) selected and after shaving and local sterilization of median dorsal region with isopropanol solution allocated randomly in 4 groups. In experiment groups (A, B and C) hydrogel-grafted suspension of each three NONOates components (DETA-NO, DPTA-NO and DPTA-NO-g-dextran) applied locally to the shaved area in each rat. Control group (D) applied with hydrogel only. Urine samples were collected and freezed in -80°C for NO content analysis using NO analyzer system.
Results: The average maximum level for urinary NO excretion was 31.8, 94.2 and 14.9 µmol/day for DETA, DPTA and DPTA-g-dextran, respectively. This value was significantly lower in DPTA-g-dextran group (P≤0.01). There was no statistically significant difference between blood pressure values before and after application of NONOates (P~0.4).
Discussion: Our results showed that transdermal application of NO-donor agents is dose-dependent. On the other hand, we found that the systemic effects of DPTA-NO-g-dextran may be much more less than that of other NO-donor agents. Hence, NO-donor agents could be accounted on as effective treatments for cutaneous infectious states.

 
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