Paper Information

Title: 

A NEW APPROACH TO NANO DRUG DELIVERY BY FULLERENE-BASED 25MG-EXCHANGING NANOPARTICLE

Type: SPEECH
Author(s): OMIDVARI A.H.,SALMANIAN B.*,ESMAEILI S.,TARIGHAT SOMAYEH,REZAYAT S.M.,ABKHIZ MOUSA
 
 *DEPARTMENT OF PHARMACOLOGY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Nanomedicine is beginning to emerge from research in nanotechnology. Nanotechnologies have features on the scale of nanometers. Nanoscale materials often have novel properties related to their high ratio of surface area and quantum effects. Biopharmaceutics is one of nanomedicine applications. Efforts are focused on drug delivery applications using nanomaterial coatings to encapsulate drugs and to serve as functional carriers. Nanomaterial encapsulation could improve the diffusion, degradation, and targeting of a drug. Furthermore, nanomaterials could serve as camouflage to avoid immune responses, or as agents which could catalyze or respond to certain molecules or chemical events. Fullerene-Based 25Mg-Exchanging Nanoparticle, a new adduct of C60-fullerene, with the ability to serve as a 25Mg2+-releasing smart nanoparticle, is recently found to be a mitochondrial membrane tropic agent for mammalian myocardiocyte. Therefore Fullerene-Based 25Mg-Exchanging Nanoparticle is a promising tool for activation of Mg2+-dependent ATP production in vivo which is especially essential in case of numerous hypoxia syndromes, as it releases 25Mg2+ in response to acidosis. Taking into account everything stated above, the elucidation of the mitochondrial membrane located Fullerene-Based 25Mg-Exchanging Nanoparticle-specific receptor is an important goal for scientific investigation which must be reached to help better understanding of which path could improve the medicinal efficiency of the drug studied. The results show the specific properties of the receptor that help to improve Fullerene-Based 25Mg-Exchanging Nanoparticle targeting and selectivity which is a key problem of the contemporary molecular pharmacology.

 
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