Paper Information

Title: 

WEB-BASED SIMULATION OF PLASMA DRUG CONCENTRATION; A MODEL FOR TEACHING CLINICAL PHARMACOKINETICS

Type: SPEECH
Author(s): BOHLOULI SH.*,BOHLOULI M.,MAHMOUDIAN MASOUD
 
 *PHARMACOLOGY DEPARTMENT, SCHOOL OF MEDICINE, ARDABIL UNIVERSITY OF MEDICAL SCIENCES (ARUMS)
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: pharmacokinetics is the science of time course of drug absorption, distribution and elimination. It also concerns the relationship of these processes to the intensity and time course of pharmacologic (therapeutic and toxic) effects of drugs. In other hand, pharmacokinetics is a quantitative science and requires a preexisting competence in mathematics. For better understanding of pharmacokinetic concepts, medical students usually have to envision the effects of interfering factors on plasma concentration of drugs. For fulfilling of this fall a web-based computer program was designed which able to simulate the plasma concentration of drugs and reflect the effects of factors such as age, weight, gender, patient creatinine and also route of drug administration, maintenance dose and loading dose on it in a 2D Graph.
Methods and Results: the required pharmacokinetic variables such as Ka (constant rate of absorption), Ke (constant rate of elimination), F (bioavailability), Vd (volume of distribution) were obtained from valid pharmacology texts and entered in database. User interface for patient and drug data input and graph displaying module were programmed with Visual Basic language.
Discussion: the ability of program to reflecting the effects of variables related to patient and drug was examined and evaluated. It supposed this program could be a suitable tool for education of clinical pharmacokinetics at courses. Besides, distance learning is possible, because of the web-based nature of program.

 
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