Paper Information

Title: 

STUDY OF TESTICULAR CYTOTOXICITY OFLOXAEIN IN RATS

Type: SPEECH
Author(s): HEYDARI M.*,PARTOU AZAR A.,GHAZI KHANSARI M.,GHAFARI M.
 
 *DEPARTMENT OF REPRODUCTIVE ENDOCRINOLOGY AND EMBRYOLOGY, REPRODUCTIVE BIOLOGY, BIOTECHNOLOGY AND INFERTILITY RESEARCH CENTER (BIB), AVESINA RESEARCH CENTER, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

IN THE LAST FEW YEARS, A MARKED DECREASE IN MALE FERTILITY HAS BEEN REPORTED. ENVIRONMENTAL FACTORS WERE RECENTLY SUSPECTED FOR THIS EFFECT. AMONG THOSE FACTORS IS THE MISUSE OF DRUGS AND IN PARTICULAR ANTIBIOTICS. THE AIM STUDY ADVERSE TESTICULAR EFFECTS OF SOME QUINOLONE MEMBERS (OFLOXACIN, CIPROFLOXACIN) IN RATS, OFLOXACIN ARE A GROUP OF ANTIBACTERIAL AGENT S WITH BROOD SPECTRUM ACTIVITY. IN THE STUDY MALE WISTAR ALBINO RATS WERE GIVEN OFLOXACIN ORALLY AT A DOSE OF 20MG/KG BODY WEIGHT PER DAY, FOR 60 SAYS, AND WERE KILLED 24H AFTER THE LAST TREATMENT. PARAMETERS OF TESTICULAR CYTOTOXICITY INCLUDED GENITAL ORGAN WEIGHTS, TESTICULAR SPERM CONUTS, EPIDIDYMAL SPERM MOTILITY AND MORPHOLOGY AND HISTOPATHOLOGIC EXAMINATIONS (BY STANDARD HEMATOXYLIN-EOSIN STAINING). AT 20MG/KG, THE WEIGHTS OF TESTIES, EPIDIDYMIDES, AND SEMINAL VESICLES WERE NOT DIFFERENT AMONG THE CONTROL GROUPS. THE NUMBER OF TESTICULAR SPERM MOTILITY AND MORPHOLOGY OF EPIDIDYMAL SPERM WERE DECREASED. HISTOLOGICAL RESULTS OF TESTES MEDICATED ABNORMALITY IN SPERMATOGENESIS AND SPERMS PRODUCTION IN SOME OF THE SOMNIFEROUS TUBULES. MOREOVER, ADMINISTRATION OF OFLOXACIN RESULTED IN MARKED TESTICULAR HISTOPATHOLOGICAL CHANGES. IT IS CONCLUDED THAT OFLOXACIN SIGNIFICANTLY IMPAIRED BOTH TESTICULAR FUNCTION AND STRUCTURE IN RATS.

 
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