Paper Information

Title: 

EFFECT OF SILYMARIN ON HEPATIC FUNCTION OF FOOD-RESTRICTED RATS

Type: SPEECH
Author(s): DEHGHAN S.A.*,BAZYAR H.
 
 *VETERINARY SCHOOL, ISLAMIC AZAD UNIVERSITY, KAZEROON BRANCH
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Silymarin is a natural hepatoprotector which is extracted from Silybum marianum. In this study, the effects of silymarin on function and histopathology of liver, serum biochemical factors and body weight were investigated in food-restricted rats.
Methods: 72 female Wistar rats were divided into 6 same groups (n=12). Control group were fed ad libitum. Rats in other groups received 50% of the food intake of control group and served as food restricted groups. Three of five food-restricted groups were received 100, 200 and 400 mg/kg silymarin, respectively. One other food-restricted group received placebo. Another food-restricted group and control group were not received any silymarin. Silymarin was administered orally for 18 days.
Results: Glucose, triglyceride, serum proteins and hepatic enzymes (ALT, AST, ALP) were assayed in serum. Serum triglycerides in food-restricted groups were lower than control group significantly (P<0.05). But, these levels were significantly higher in 100 mg silymarin group than control food-restricted group (P<0.05). Food restriction caused to significant decrease in AST and ALP than control group which may related to decrease in protein synthesis. The other serum parameters were not significantly different. Also, changes in body weight were shown significant differences between groups (P<0.05). Results from liver histopathology indicate that food restriction have limited pathologic effects on biliary system of placebo and food-restricted control groups; although there were no important tissue injuries in control and treatment groups (P>0.05).
Conclusion: Results showed that food restriction not only have not major side effect on liver hepatobiliary system, but also it can reduce fat infiltration in hepatocytes. Also, silymarin can support liver function by increasing in protein synthesis and reduce weight loss in food restriction.

 
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