Paper Information

Title: 

CARDIOVASCULAR EFFECTS OF NOSCAPINE

Type: POSTER
Author(s): SHAFIEI M.*,CHALIAN M.,MOURAKI A.,ABOTALEB N.,BEIRANVAND F.,RAIGAN S.,GHANE M.,MAHMOUDIAN MASOUD
 
 *DEPARTMENT OF PHARMACOLOGY & RAZI INSTITUTE FOR DRUG RESEARCH
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: It has been shown that noscapine could antagonize bradykinin (BK)-induced responses. Regarding some new applications and the role of BK in the cardiovascular system, cardiovascular effects of noscapine were evaluated.
Methods: In a double-blinded, placebo-controlled crossover study, we assessed the effect of noscapine (15 mg, p.o., tid) on the blood pressure and pulse rate of 24 healthy volunteers. The interaction of BK and noscapine was also examined in isolated human umbilical artery (HUA). Moreover, the effects of noscapine alone on the vascular tone and atrial rate and contraction in isolated rat aorta and guinea pig atria, respectively, were evaluated.
Results: 1) Noscapine did not change the blood pressure and pulse rate of healthy volunteers. 2) Noscapine could antagonize the constriction produced by BK in HUA in vitro. 3) Noscapine dilated endothelium-lined rat aorta. Significant reduction in the dilatory response of aortic segments was shown in presence of indomethacin (10-5 M) or L-NMMA (2×10-4 M). 4) Atrial contractility increased whereas spontaneous atrial rate decreased with cumulative concentrations of noscapine.
Conclusion: Noscapine could interact with BK in the human vascular model. The drug caused a direct vasodilation, partly dependent to the COX and NO pathways, and exerted positive inotropic and negative chronotropic effects but it seems that serum levels much higher than those could be obtained with conventional dosage are necessary to produce marked direct cardiovascular effects as noscapine did not affect the blood pressure and pulse rate of healthy volunteers.

 
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