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Paper Information

Title: 

THE EFFECT OF ESTROGEN ON SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR AND NITRIC OXIDE CONCENTRATIONS IN OVARIECTOMIZED RATS

Type: SPEECH
Author(s): KHAZAEI M.,NEMATBAKHSH M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: cardiovascular disease (CVD) is the leading cause of death in developed countries. Previous studies have shown that hormone replacement therapy reduces the risk of CVD in postmenopausal women. This study was designed to evaluate the effect of estrogen on serum Vascular Endothelial Growth Factor (VEGF) and Nitric Oxide (NO) concentrations in ovariectomized rats.
Methods: 19 female rats were ovariectomized and randomly divided into two groups: estrogen-treated and control. Estradiol valerate was injected 2 mg i.m once a week for six weeks. Control group received normal saline. Serum VEGF and NO concentrations were measured before and after estrogen treatment.
Results: results showed that serum VEGF concentrations in estorgen-treated animals were higher than control (268.77± 41.02, 106.44 ± 36.27 pg/ml, respectivley) (P<0.05). Also, there was significant difference in serum NO concentrations in estrogen-treated group and control (90.200 ± 18.66, 40.86 ± 12.08 μmol/lit, respectively) (P<0.05).
Conclusion: it is possible that the increasing in serum VEGF and NO concentrations after estrogen therapy contributes to the cardiovascular effects of estrogen.

 
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