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Paper Information

Title: 

THE EFFECT OF INTERMITTENT AND PROLONGED NORMOBARIC HYPEROXIA ON BRAIN EDEMA AND BLOOD BRAIN BARRIER PERMEABILITY IN THE RAT BRAIN STROKE MODEL

Type: SPEECH
Author(s): BIGDELI M.R.,HAJIZADEH S.,KHOUSHBATEN A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Ischemic preconditioning (IPC) is an endogenous phenomenon that can induce ischemic tolerance (IT) in variety of organs such as brain. Noxious stimuli applied at close to but below the threshold of cell injury induce adaptive response that protect the brain against additional stress from the same (tolerance) or other (cross-tolerance) stimuli. In this study, we examined the intermittent and prolonged dose of normobaric hyperoxia (NBHO) on neurologic deficit scores, brain edema, and blood brain barrier (BBB) permeability after middle cerebral artery occlusion (MCAO).
Material and Method: The rats were exposed with NBHO in prolonged (24h) and intermittent (4h*6days) groups. After 24 h, they were subjected to 60 minutes MCAO followed by 24h of reperfusion. Then, IT induced by intermittent and prolonged NBHO were measured by neurologic deficit scores, brain edema by weighting of ischemic and non-ischemic hemispheres in control, sham, and experimental groups, and BBB permeability by measurement of Evans Blue (EB) extravasations concentration of ischemia and non-ischemic hemispheres in control, sham, and experimental groups.
Result:  our finding indicate that intermittent and prolonged NBHO are involved in the induction of IT. Pretreatment with prolonged and intermittent NBHO reduced neurologic deficit scores significantly, whereas reduction of brain edema and EB extravasations in prolonged NBHO was not significant. EB extravasations and brain edema were decreased in intermittent NBHO significant.  EB extravasations and brain were decreased in intermittent NBHO significantly.
Conclusion: intermittent NBHO has low toxicity and side effect. On the other hand, intermittent NBHO is acceptable for clinical use and has stronger effect than prolonged NBHO on IT induction.

 
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