Paper Information

Title:  EFFECT OF SEX HORMONES ON EDEMA FORMATION AFTER DIFFUSE TRAUMATIC BRAIN INJURY IN FEMALE RAT
Type: SPEECH
Author(s): KHAKSARI HADAD M.,AHMAD MOULAEI L.,DABIRI SH.,MOSHTAGHI GH.R.,ASADI KARAM GH.R.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objectives and background: Nowadays sex hormones (estrogen and progesterone) are considered as neuroprotective factors after brain injury. In this study effect of sex hormones as a single dose one hour after diffuse traumatic brain injury was investigated.
Methods and materials: This experimental study was performed on 12 groups of male and female rats as follows; every group was included 2 subgroups, in one subgroup Evans blue and in another one water content were measured. 1,2 groups: male and female control, 3,4 groups: trauma male and female, 5 group: vehicle of estrogen and progesterone, 6 group: sham(ovariectomized female rat:ovx), 7 group: sham (no ovx), 8 group: sham (male), 9,10 groups: low (0/1mg/kg) and high dose (1mg/kg) of estrogen, 11, 12 groups: low (4mg/kg) and high dose (8mg/kg) of progesterone. Hormones injected i.p. Injury was induced using closed head injury model of Marmarou.
Findings: Evans Blue and water content in trauma male rats significantly increased as compared to control, But in female rats, it was just significant for Evans Blue, Also Evans Blue and water content in trauma male rat were greater (significant) than trauma female rat. After injection of low and high dose of estrogen and progesterone Evans blue and water content were significantly decreased.
Conclusion: Edema formation in trauma male rat was significantly increased compared to trauma female rat, also after injection of estrogen and progesterone after diffuse traumatic brain injury, brain edema was decreased in ovariectomized female rat.

 
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