Paper Information

Title: 

EFFECT OF SAFFRON EXTRACT ON THE INDUCTION AND EXPRESSION OF MORPHINE-DEPENDENCE IN MICE

Type: SPEECH
Author(s): KHAKPOUR B.*,ROSTAMPOUR M.,NOURASFARD M.R.,SAHRAEI HEDAYAT
 
 *GUIL UNIVERSITY OF MEDICAL SCIENCES CELLULAR AND MOLECULAR RESEARCH CENTER
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Saffron extract (SE) can prevent induction and expression of morphine-induced locomotor sensitization. In the present study the effect of SE on the induction and expression of morphine dependence as its effect on naloxane-induced withdrawal syndrome were investigated.
Methods: In order to develop dependence, morphine sulfate were injected three times daily for 3 days. The first day doses were 50, 50 and 75 mg/kg. In two other days injected doses increased 25 mg/kg/day. In day 4th, a single dose morphine (50 mg/kg) was administrated .Two hours after the 10th injection of morphine, naloxane (4mg/kg) was injected and the number of jumps and dry and wet defecation were measured. For the assessment of the effect of SE on dependence- induction, saline (10 ml/kg) and different doses of extract (10, 50, 100 mg/kg) were injected in first 3 days , 30 min. before morphine injection. For assessment of the effect of SE on dependence - expression, saline and the doses of extract were injected 30 min. before naloxane injection.
Results: Results showed that all doses of SE prevented dependence - expression. Both, number of jumps (P<0.01) and the amount of defecation (p<0.05) decreased. Only 100 mg/kg extract was effective on dependence - induction and could decreased defecation (p<0.01).
Conclusion: Saffron extract can ameliorate withdrawal syndrome signs in morphine-dependent mice.

 
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