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Paper Information

Title: 

EFFECTS OF ESTROGEN IN INDUCTION OF APOPTOSIS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Type: SPEECH
Author(s): MAHMOUDI M.,RASTIN M.,HATEF M.R.,TABASI N.A.,SHEYKHI A.,MORAD ABBASI J.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Systemic lupus erythematosus is an autoimmune disease which mostly occurs in women during their childbearing years. Etiology is unknown but environmental, genetic and infectious factors are important and the strongest risk factor for development of SLE is female gender and hormones. Estrogen enhances immune responses and induces apoptosis, in apoptotic cells some epitopes which there are no tolerance against them are exposed to immune system cells. Previous studies demonstrate the effects of estrogen in induction of apoptosis in animal models and cell lines. In this study we investigated the effects of estrogen on T lymphocytes apoptosis in SLE patients.
Methods: Study group comprised of 35 SLE patients, and 20 age and sex matched controls. T lymphocytes cultured with 17-B estradiol, then cells stained with anti-CD95 FITC, anti-CD3 PE, Annexin V FITC, and PI and analyzed on a BD flow cytometer.
Results
and Conclusion: Estrogen enhanced percentage of TCD95+ cells , and percentage of apoptotic T cells which are Annexin V positive and PI negative in SLE patients and in control group but increase in SLE patients are more than controls, which implies more susceptibility of SLE patients to estrogen (p<0.05).

 
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