COMPUTATIONAL STUDIES ON THE INTERACTIONS OF MAGNOLOL AND HONOKIOL WITH HUMAN SERUM ALBUMIN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARIFI TAYEBEH; FANI NAJMEH; GHAYEB YOUSEF

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN SEMINAR OF ANALYTICAL CHEMISTRY
Year:2014 | Issue:20

Download Full-Text

View:

401

Download:

Information Seminar Paper

Title

COMPUTATIONAL STUDIES ON THE INTERACTIONS OF MAGNOLOL AND HONOKIOL WITH HUMAN SERUM ALBUMIN

Author(s)

SHARIFI TAYEBEH | FANI NAJMEH | GHAYEB YOUSEF | Issue Writer Certificate

Keywords

Not Registered.

Abstract

MAGNOLIA BALK EXTRACT (MBE) USED IN ASIAN TRADITIONAL MEDICINE FOR THE TREATMENT OF ANXIETY, SLEEPING DISORDERS, AND ALLERGIC DISEASES [1]. MAGNOLOL (MG) AND HONOKIOL (HK) ARE THE TWO PRIMERY ACTIVE PHENOLIC CONSTITUENT OF MBE. SINCE BIOACTIVE COMPONENTS OF MBE ARE POTENTIAL HERBAL DRUGS, IT WAS OF INTEREST TO OBTAIN INSIGHT IN TO THEIR BINDING AFFINITIES WITH THE CARRIER PROTEINS SUCH AS HUMAN SERUM ALBUMIN (HSA) USING EXPERIMENTAL TECHNIQUES AND MOLECULAR MODELING.HUMAN SERUM ALBUMIN (HSA) IS PLENTIFUL PLASMA PROTEIN THAT HAS A GREATLY TRANSPORT CAPACITY OF BLOOD PLASMA AND ABILITY OF BINDING FOR MANY OF SUBSTANCE. ITS SINGLE POLYPEPTIDE CHAIN CONSIST OF 585 AMINO ACIDS WITH THREE A-HELICAL DOMAINS (I, II, AND III) AND EACH DOMAIN CONTAINS TWO SUBDOMAIN A AND B. THREE BINDING REGIONS OF HSA ARE LOCATED IN SUBDOMAIN IIA, IIIA, AND IB THAT ARE WELL KNOWN SITE1, SITE2, AND SITE3 RESPECTIVELY [2].IN THE PRESENT WORK BINDING MODES, BINDING FREE ENERGIES AND INHIBITION CONSTANTS, (KI), BETWEEN OF HSA-MG AND HSA-HK SYSTEMS HAVE BEEN INVESTIGATED BY USING MOLECULAR DOCKING METHOD.MOLECULAR DOCKING RESULTS INDICATED THAT THE MAIN ACTIVE BINDING SITE FOR MG IS SITE1. ALSO THE MAIN ACTIVE BINDING SITE FOR HK IS SITE2. THE RESULTS ARE LISTED IN TABLE 1.TABLE1: AMINO ACID RESIDUES INVOLVED IN HSA-MG AND HSA-HK SYSTEMS INTERACTION WITH THE FREE BINDING ENERGY FOR THE BEST SELECTED DOCKING POSITIONS.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

SHARIFI, TAYEBEH, FANI, NAJMEH, & GHAYEB, YOUSEF. (2014). COMPUTATIONAL STUDIES ON THE INTERACTIONS OF MAGNOLOL AND HONOKIOL WITH HUMAN SERUM ALBUMIN. IRANIAN SEMINAR OF ANALYTICAL CHEMISTRY. SID. https://sid.ir/paper/912852/en

Vancouver: Copy

SHARIFI TAYEBEH, FANI NAJMEH, GHAYEB YOUSEF. COMPUTATIONAL STUDIES ON THE INTERACTIONS OF MAGNOLOL AND HONOKIOL WITH HUMAN SERUM ALBUMIN. 2014. Available from: https://sid.ir/paper/912852/en

IEEE: Copy

TAYEBEH SHARIFI, NAJMEH FANI, and YOUSEF GHAYEB, “COMPUTATIONAL STUDIES ON THE INTERACTIONS OF MAGNOLOL AND HONOKIOL WITH HUMAN SERUM ALBUMIN,” presented at the IRANIAN SEMINAR OF ANALYTICAL CHEMISTRY. 2014, [Online]. Available: https://sid.ir/paper/912852/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops