Paper Information

Title: 

EFFECT OF CAPSAICIN INDUCED C-FIBER DEPLETION, ON EXPERIENCE DEPENDENT PLASTICITY IN MALE RAT BARREL CORTEX

Type: POSTER
Author(s): SHEYBANI VAHID,SHAMSIZADEH ALI,AFARINESH M.R.,ARABZADEH SOMAYEH
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

C-fibers can modulate receptive field properties, spontaneous activity and spatio-temporal interactions in barrel cortex neurons. We investigated the role of C-fibers depletion on response properties of barrel neurons (layer IV) following experience dependent plasticity. C-fiber depletion was induced by neonatal treatment with capsaicin (50 mg/kg, I.P). Plucking of all whiskers but D2 on the left muzzle started at first post partum day. One month later, neuronal ON and OFF responses were computed following principal whisker (PW) and adjacent whisker (AW) deflections. In both c-fiber depleted and vehicle treated rats, whisker plucking increased ON responses to spared PW deflection (P<0.05). Neuronal ON responses to deflection of deprived AW were decreased in vehicle treated rats (P<0.05) but in C-fiber depleted rats they did not decrease. Neuronal OFF responses showed similar results. These results suggest that following experience dependent plasticity, C-fibers can modulate response properties of neurons in barrel cortex.

 
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