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Paper Information

Title: 

EVALUATION OF THE EFFECT OF CHRONIC STIMULATION OF 5-HT1A RECEPTORS IN DORSAL RAPHE NUCLEUS ON APOPTOSIS PROCESSING IN THIS NUCLEUS DUE TO THE CHRONIC ADMINISTRATION OF MORPHINE IN MALE RATS

Type: SPEECH
Author(s): CHARKHPOUR M.*,DOUSTAR Y.,NAYEBI A.M.
 
 *DEPT. OF PHARMACOLOGY & TOXICOLOGY, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In the past studies has been shown that the chronic intra DRN administration of specific 5-HT1A agonists (for example 8-OH-DPAT) with morphine, delayed tolerance to analgesic effect of morphinein male rats. In the other way, established that the chronic administration of morphine, in opposite of acute effect, has apoptotic effect on neuronal cells. In addition, has been shown that the chronic administration of some specific 5-HT1A agonists have been antiapoptotic effect.
Methods: Experiments were performed on 9 groups (n=8) adult male wistar rats weighing between 200 and 250 g. The intact rats, saline group (0.5ml/kg,i.p.) and morphine group (5mg/kg,i.p.), 8-OH-DPAT group (8µg/µl/2min) and vehicle (1µl/2min) into the DRN, 3 groups of 8-OH-DPAT (2,4,8 µg/µl/2min) with morphine and vehicle of 8-OH-DPAT with morphine. Chronic injections of morphine continued until the development of tolerance to analgesic effect of morphine in hot-plate test. At the end, we investigate the apoptosis wieh TUNEL test in rats.
Results: Results have shown that the chronic administration of 8-OH-DPAT with morphine, dose dependently decrease the tolerance to antinociceptive effect of morphine and apoptosis in DRN.
Conclusion: The chronic stimulation of 5-HT1A receptors in DRN caused by attenuation of tolerance to analgesic effect of morphine simultaneously inhibition of apoptosis in that nucleus.

 
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