Paper Information

Title: 

STRESS AND CARBOHYDRATE METABOLISM

Type: PAPER
Author(s): ZAHEDIASL S.*
 
 *ENDOCRINE RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Stress is defined as the state in which the brain interprets the quantity of stimulation as excessive or its quality as threatening. Exposure to hostile conditions results in a series of important adaptive responses that enable an organism to cope with a changing environment. Stress, especially "adequate" acute stress i.e., stress that is not "overwhelming" - may improve performance and thus in certain cases be beneficial. However, when prolonged or repeated, stress can be extremely harmful. Stress stimulates several adaptive hormonal responses, prominent among which are the secretion of catecholamines from the adrenal medulla and corticosteroids from the adrenal cortex. Although human studies conducted on the role of stress in the onset and course of type 2 diabetes are limited, a large body of animal studies supports the notion that stress reliably produces hyperglycemia. It has been shown that acute environmental stress causes a transient increase in blood glucose, which results perhaps from a derangement of insulin secretion and insulin sensitivity due to changes in hormones involved in glucose metabolism. However, expression of the diabetes phenotype is reduced by chronic stress, as a result of inhibition of weight gain due to a decrease in food intake, which leads to improvement in insulin sensitivity. According to our findings chronic psychological stress decreases body weight, food intake, and plasma insulin concentration after oral glucose tolerance test while increasing insulin release from the isolated islets. It appears that the type of the stress is an important determinant of the effect.

 
Keyword(s): 
 
Yearly Visit 19   tarjomyar
 
Latest on Blog
Enter SID Blog